Title : 6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats.

Pub. Date : 2010 Aug

PMID : 20464434






2 Functional Relationships(s)
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1 Animals receiving 6-mp thus showed a significant decrease in IL-1 and TNF-alpha (18/43% and 48/64% in CSF/serum, respectively) when compared with the pMCAO groups (p < 0.01). Mercaptopurine tumor necrosis factor Rattus norvegicus
2 These findings also offer first evidence that 6-mp may attenuate TNF-alpha-related neuron apoptosis and also support the notion that 6-mp and other anti-inflammatory agents could potentially have therapeutic uses in cases of cerebral infarct. Mercaptopurine tumor necrosis factor Rattus norvegicus