Title : Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting.

Pub. Date : 2010 Jun

PMID : 20455087






1 Functional Relationships(s)
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1 The RA/arsenic trioxide association, which dramatically synergizes for PML/RARA degradation but not for differentiation, rapidly clears LIC in a proteasome-dependent manner, resulting in APL eradication in murine models and patients. Arsenic Trioxide promyelocytic leukemia Mus musculus