Title : Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting.

Pub. Date : 2010 Jun

PMID : 20455087






2 Functional Relationships(s)
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1 Both retinoic acid (RA) and arsenic trioxide directly target PML/RARA-mediated transcriptional repression and protein stability, inducing rapid differentiation of the promyelocytes and clinical remission in most APL patients. Tretinoin PML nuclear body scaffold Homo sapiens
2 Both retinoic acid (RA) and arsenic trioxide directly target PML/RARA-mediated transcriptional repression and protein stability, inducing rapid differentiation of the promyelocytes and clinical remission in most APL patients. Tretinoin PML nuclear body scaffold Homo sapiens