Title : Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation?

Pub. Date : 2010 Aug

PMID : 20455021






3 Functional Relationships(s)
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1 MB- and PQ-treatment induced nitrite content, expressions of iNOS mRNA and protein and lipid peroxidation as compared with respective controls. Paraquat nitric oxide synthase 2, inducible Mus musculus
2 Genistein, SB202190 and PDTC reduced the expression of iNOS mRNA, nitrite content and lipid peroxidation in MB- and PQ-treated mouse striatum. Paraquat nitric oxide synthase 2, inducible Mus musculus
3 The results obtained demonstrate that nitric oxide contributes to an increase of MB- and PQ-induced lipid peroxidation in mouse striatum and tyrosine kinase, p38 MAPK and NF-kB regulate iNOS expression. Paraquat nitric oxide synthase 2, inducible Mus musculus