Title : p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.

Pub. Date : 2010 Jul 8

PMID : 20453878






1 Functional Relationships(s)
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1 We provide evidence that the antitumor effect on combination treatment is achieved by VPA-induced reactivation of p21, which is downregulated in aRMS cells by destabilization of the transcriptional regulator EGR1 by PAX3/FKHR. Valproic Acid H3 histone pseudogene 16 Homo sapiens