Title : Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.

Pub. Date : 2010 Jun 1

PMID : 20452769






1 Functional Relationships(s)
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1 Compounds 25-31 having a secondary amine moiety connected to the phenyl ring via eight CH(2) units spacer were found to be the most potent inhibitors with IC(50) value lower than 220nM and 48nM against AChE and BChE, respectively. Amines acetylcholinesterase (Cartwright blood group) Homo sapiens