Title : Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro.

Pub. Date : 2010 Sep 6

PMID : 20452337






3 Functional Relationships(s)
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1 Here, we searched potential AChE inhibitors from flavonoids, a group of naturally occurring compounds in plants or traditional Chinese medicines (TCM). Flavonoids acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Twenty-one flavonoids, covered different subclasses, were tested for their potential function in inhibiting AChE activity from the brain in vitro. Flavonoids acetylcholinesterase (Cartwright blood group) Homo sapiens
3 showed an inhibitory effect on AChE activity with the highest inhibition by over 55% and an IC(50) of 120 microM and an enzyme-flavonoid inhibition constant (K(i)) of 74 microM. Flavonoids acetylcholinesterase (Cartwright blood group) Homo sapiens