Pub. Date : 2010 May 25
PMID : 20448202
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although a key factor in Alzheimer"s disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 2 | Although a key factor in Alzheimer"s disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 3 | By covalently linking fragments (that have experiment-based coordinates) we observed that, in oligomeric Zn(2+)-Abeta(42), Zn(2+) can simultaneously coordinate intra- and intermolecularly, bridging two peptides. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 4 | Overall, Zn(2+) coordination promotes Abeta(42) aggregation leading to less uniform structures. | Zinc | amyloid beta precursor protein | Homo sapiens |