Title : Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells.

Pub. Date : 2010 Jul

PMID : 20442653






5 Functional Relationships(s)
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1 The level of testosterone regulating several signaling pathways, including extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun-N-terminal kinase (JNK), and p38 MAPK, was measured by western blot in HUVECs. Testosterone mitogen-activated protein kinase 8 Homo sapiens
2 The level of testosterone regulating several signaling pathways, including extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun-N-terminal kinase (JNK), and p38 MAPK, was measured by western blot in HUVECs. Testosterone mitogen-activated protein kinase 8 Homo sapiens
3 Testosterone-induced a rapid phosphorylation of ERK1/2, JNK and p38 MAPK in HUVECs, which could not be inhibited by androgen receptor antagonist flutamide. Testosterone mitogen-activated protein kinase 8 Homo sapiens
4 Blocking ERK1/2 or JNK pathway could significantly impair testosterone-induced TFPI at both translational and transcriptional levels in HUVECs. Testosterone mitogen-activated protein kinase 8 Homo sapiens
5 Testosterone at a physiological concentration may help to prevent thrombosis development by stimulating TFPI expression in HUVECs, partly through the ERK1/2 and JNK MAPK pathway. Testosterone mitogen-activated protein kinase 8 Homo sapiens