Title : Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.

Pub. Date : 2010 Jul 2

PMID : 20442406






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation. Tetradecanoylphorbol Acetate integrin subunit alpha 2b Homo sapiens
2 In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation. Tetradecanoylphorbol Acetate integrin subunit alpha 2b Homo sapiens