Title : Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells.

Pub. Date : 2010 Jun

PMID : 20428768






3 Functional Relationships(s)
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1 Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens
2 The phosphorylations of both p38 MAP kinase and p53 induced by doxorubicin were suppressed by low doses of ionizing radiation. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens
3 The results thus suggest that low doses of radiation suppress doxorubicin-induced replicative senescence through the inhibition of p38-dependent phosphorylation of p53 and by activation of ERK1/2, without genomic damage. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens