Title : Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells.

Pub. Date : 2010 May

PMID : 20418897






3 Functional Relationships(s)
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1 This inhibition is attributed to GA interruption of both JNK/c-Jun and I kappaB/NF-kappaB signaling pathways, which decrease activator protein-1 (AP-1) and NF-kappaB mediated ICAM-1 expressions. Glycyrrhetinic Acid Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 This inhibition is attributed to GA interruption of both JNK/c-Jun and I kappaB/NF-kappaB signaling pathways, which decrease activator protein-1 (AP-1) and NF-kappaB mediated ICAM-1 expressions. Glycyrrhetinic Acid Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 This inhibition is attributed to GA interruption of both JNK/c-Jun and I kappaB/NF-kappaB signaling pathways, which decrease activator protein-1 (AP-1) and NF-kappaB mediated ICAM-1 expressions. Glycyrrhetinic Acid Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens