Title : Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases.

Pub. Date : 2010 May 28

PMID : 20416277






1 Functional Relationships(s)
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Protein Name
Organism
1 Oxygen- and 2-oxoglutarate (2-OG)-dependent, iron(II) containing HIF-specific prolyl-4-hydroxylases (PHDs) and factor inhibiting HIF-1alpha (FIH-1) catalyze the hydroxylation of the specific proline and asparagine residues of HIF-1alpha, thereby controlling the level of HIF-1alpha and ultimately the HIF response. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens