Title : Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production.

Pub. Date : 2010 Apr 22

PMID : 20413096






2 Functional Relationships(s)
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1 Here, we show that nAchR activation by topical agonist application or deletion of the nAChR antagonist catestatin (Chga(-/-)) reduced antimicrobial peptide (AMP) activity in skin extracts and increased susceptibility to methicillin-resistant Staphylococcus aureus and Group A Streptococcus infections. Methicillin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Here, we show that nAchR activation by topical agonist application or deletion of the nAChR antagonist catestatin (Chga(-/-)) reduced antimicrobial peptide (AMP) activity in skin extracts and increased susceptibility to methicillin-resistant Staphylococcus aureus and Group A Streptococcus infections. Methicillin cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus