Title : Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy.

Pub. Date : 2010 Apr 21

PMID : 20410122






2 Functional Relationships(s)
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1 Furthermore, overexpression of TbetaRII dampens polyglutamine-induced cytotoxicity in a neuroblastoma cell line expressing the pathogenic AR. polyglutamine androgen receptor Homo sapiens
2 The present study thus indicates that disruption of TGF-beta due to the transcriptional dysregulation of TbetaRII is associated with polyglutamine-induced motor neuron damage in SBMA. polyglutamine androgen receptor Homo sapiens