Title : Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.

Pub. Date : 2010 Jul 25

PMID : 20406630






3 Functional Relationships(s)
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1 (1) Sodium salicylate, a non-COX-selective NSAID, was shown to reduce DNA damage-induced RPA and p53 phosphorylation. Sodium Salicylate tumor protein p53 Homo sapiens
2 (5) The activation of ataxia telangiectasia mutated (ATM) kinase and DNA-dependent protein kinase (DNA-PK), two key signal transducers upstream of RPA and p53, was found to be significantly reduced with sodium salicylate treatment. Sodium Salicylate tumor protein p53 Homo sapiens
3 (7) Unexpectedly, sodium salicylate showed a p53-independent protection effect on topoisomerase-mediated cell killing. Sodium Salicylate tumor protein p53 Homo sapiens