Title : HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells.

Pub. Date : 2010 May 15

PMID : 20404718






2 Functional Relationships(s)
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1 Additionally, Vpr-induced cleavage of BID to tBID and suppression of BID expression prevented Vpr-induced apoptosis. tBID BH3 interacting domain death agonist Homo sapiens
2 CONCLUSIONS: These studies delineate a novel pathway of Vpr-induced apoptosis in RTEC, which is mediated by sustained ERK activation, resulting in caspase 8-mediated cleavage of BID to tBID, thereby facilitating Bax-mediated mitochondrial injury and apoptosis. tBID BH3 interacting domain death agonist Homo sapiens