Title : Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Pub. Date : 2010 Aug

PMID : 20403969






1 Functional Relationships(s)
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1 Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. Phenobarbital nuclear receptor subfamily 1, group I, member 2 Mus musculus