Pub. Date : 2010 Jul
PMID : 20400470
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, we observed greater differences in the rates of clearance of oral BaP, between WT and IE-Cpr-null mice, in mice pretreated with beta-naphthoflavone, to induce CYP1A1 expression, than in untreated mice. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | The onset of induction (at 2 h after dosing) of CYP1A1 protein expression by oral BaP administration was earlier in the SI than in extra-gut organs analyzed; for liver, lung, and kidney, induction was not observed until 4 h after dosing. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Taken together, these findings strongly support the concept that small-intestinal CYP1A1 induction is a critical factor in protection against systemic exposure to oral BaP. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |