Title : Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts.

Pub. Date : 2010 Apr 15

PMID : 20398340






2 Functional Relationships(s)
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1 Inhibitors of JNK and NF-kappaB also decreased the TNFalpha-stimulated up-regulation of mPGES-1 and COX-2 as well as PGE2 production. Dinoprostone mitogen-activated protein kinase 8 Homo sapiens
2 The involvement of the signal pathways JNK and NF-kappaB in the regulation of PGE2 induced by TNFalpha may suggest these two pathways as possible attractive targets in the chronic inflammatory disease periodontitis. Dinoprostone mitogen-activated protein kinase 8 Homo sapiens