Pub. Date : 2010
PMID : 20386083
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers. | Darunavir | CD9 molecule | Homo sapiens |
| 2 | We studied MRP1 expression and function in healthy volunteers treated with darunavir/ritonavir and efavirenz. | Darunavir | CD9 molecule | Homo sapiens |
| 3 | MRP1 efflux function was increased after efavirenz administration (GMR 3.13, 95% CI 2.73-3.59; P<0.001) and darunavir/ritonavir plus efavirenz coadministration (GMR 4.35, 95% CI 3.35-5.68; P<0.001), but not after darunavir/ritonavir administration (GMR 1.06, 95% CI 0.80-1.42; P=0.42). | Darunavir | CD9 molecule | Homo sapiens |
| 4 | MRP1 efflux function was increased after efavirenz administration (GMR 3.13, 95% CI 2.73-3.59; P<0.001) and darunavir/ritonavir plus efavirenz coadministration (GMR 4.35, 95% CI 3.35-5.68; P<0.001), but not after darunavir/ritonavir administration (GMR 1.06, 95% CI 0.80-1.42; P=0.42). | Darunavir | CD9 molecule | Homo sapiens |
| 5 | CONCLUSIONS: Darunavir/ritonavir and efavirenz treatment exerted differential effects on MRP1 expression and function. | Darunavir | CD9 molecule | Homo sapiens |