Pub. Date : 2010 Jul
PMID : 20375080
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite. | arsenite | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2. | arsenite | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2. | arsenite | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Moreover, inactivation of NF-kappaB facilitated p53-mediated DNA repair and prevented arsenite-induced malignant transformation. | arsenite | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite-induced malignant transformation of human keratinocytes. | arsenite | nuclear factor kappa B subunit 1 | Homo sapiens |