Title : Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives.

Pub. Date : 2010 Mar 1

PMID : 20369030






1 Functional Relationships(s)
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1 AEDs, such as phenytoin, phenobarbital, carbamazepine, felbamate, topiramate, oxcarbazepine and primidone, induce cytochrome P450 3A4, leading to enhanced metabolism of either or both the estrogenic and progestogenic component of OCs, thereby reducing their efficacy in preventing pregnancy. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens