Pub. Date : 2010 Jul
PMID : 20359293
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of budesonide on TGF-beta1-enhanced VEGF production by lung fibroblasts. | Budesonide | vascular endothelial growth factor A | Homo sapiens |
| 2 | Since the glucocorticoids have shown antifibrosis properties, we sought to investigate whether budesonide, a widely used glucocorticoid in clinical practice, could attenuate TGF-beta1 (transforming growth factor-beta1)-induced VEGF production by HFL-1 (human lung fibroblasts). | Budesonide | vascular endothelial growth factor A | Homo sapiens |
| 3 | The results suggested that budesonide pretreatment reduced the significant increase of VEGF release induced by TGF-beta1 in HFL-1 fibroblasts in a dose-dependent manner, and suppressed the increase of phospho-Smad3 and phosphor-ERK (extracellular signal-regulated kinase) protein levels. | Budesonide | vascular endothelial growth factor A | Homo sapiens |
| 4 | In conclusion, budesonide may reduce TGF-beta1-induced VEGF production in the lung, probably through the Smad/ERK signalling pathway and, thus, may provide new sight into the molecular mechanism underlying glucocorticoid therapy for airway inflammatory diseases. | Budesonide | vascular endothelial growth factor A | Homo sapiens |