Title : 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5.

Pub. Date : 2010 May 12

PMID : 20356045






4 Functional Relationships(s)
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1 6-DG also up-regulated Ser-15 phosphorylation and evoked p53 nuclear translocation. 6-dehydrogingerdione tumor protein p53 Homo sapiens
2 Abrogation of p53 expression by p53 small interfering RNA significantly attenuated 6-DG-induced DR5 expression, thus rendering these cells resistant to TRAIL-induced apoptosis. 6-dehydrogingerdione tumor protein p53 Homo sapiens
3 Abrogation of p53 expression by p53 small interfering RNA significantly attenuated 6-DG-induced DR5 expression, thus rendering these cells resistant to TRAIL-induced apoptosis. 6-dehydrogingerdione tumor protein p53 Homo sapiens
4 Taken together, these data suggested that in addition to the mitochondrial- and Fas receptor-mediated apoptotic pathways involved, ROS-dependent and p53-regulated DR5 expression was also demonstrated to play a pivotal role in the synergistic enhancement of TRAIL-induced apoptosis instigated by 6-DG in Hep G2 cells. 6-dehydrogingerdione tumor protein p53 Homo sapiens