Pub. Date : 2010 Jun
PMID : 20348036
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils. | Ropivacaine | integrin subunit alpha M | Homo sapiens |
| 2 | The aim of this study was to investigate anti-inflammatory properties of ropivacaine with regard to its effects on the expression and function of CD11b in human neutrophils. | Ropivacaine | integrin subunit alpha M | Homo sapiens |
| 3 | Ropivacaine inhibited CD11b expression in formyl-methionyl-leucyl-phenylalanine (fMLP)-activated neutrophils in a concentration-dependent manner, but not in a time-dependent manner. | Ropivacaine | integrin subunit alpha M | Homo sapiens |
| 4 | The up-regulation of CD11b induced by platelet-activating factor (PAF) priming was also inhibited by ropivacaine. | Ropivacaine | integrin subunit alpha M | Homo sapiens |
| 5 | In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+). | Ropivacaine | integrin subunit alpha M | Homo sapiens |
| 6 | Our results suggest that ropivacaine exerts anti-inflammatory activity, and this appears to be mediated through inhibiting the expression and function of adhesion molecule CD11b in neutrophils. | Ropivacaine | integrin subunit alpha M | Homo sapiens |