Title : Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier.

Pub. Date : 2010 Jul

PMID : 20347189






1 Functional Relationships(s)
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1 By employing pharmacophore-based design and the privileged fragments reassembly, a series of piperidine-/tropane-/piperazine-bridged CCR5 antagonists were designed and synthesized via an efficient convergent synthesis strategy, with focus on the optimal choice of the basic center carrier structure. Piperazine C-C motif chemokine receptor 5 Homo sapiens