Title : Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells.

Pub. Date : 2010 May 14

PMID : 20346929






2 Functional Relationships(s)
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1 The expression of anti-apoptotic protein Bcl-2 decreased, whereas the apoptotic protein Bax increased in a dose-dependent manner during butyrate-induced apoptosis. Butyrates BCL2 apoptosis regulator Homo sapiens
2 Butyrate triggered the caspase apoptotic pathway, indicated by an enhanced Bax-to-Bcl-2 expression ratio and caspase cascade reaction, which was blocked by SP600125. Butyrates BCL2 apoptosis regulator Homo sapiens