Pub. Date : 2010 Jun
PMID : 20346018
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. | Nickel | filaggrin | Homo sapiens |
| 2 | BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. | Nickel | filaggrin | Homo sapiens |
| 3 | BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. | Nickel | filaggrin | Homo sapiens |
| 4 | We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. | Nickel | filaggrin | Homo sapiens |
| 5 | Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in "bypassing" of the filaggrin proteins. | Nickel | filaggrin | Homo sapiens |
| 6 | OBJECTIVES: To investigate the association between FLG null mutations and (nickel) contact sensitization. | Nickel | filaggrin | Homo sapiens |
| 7 | A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8 3% vs. 2 4%; odds ratio (OR) 3 71, 95% confidence interval (CI) 0 73-18 96] as well as between FLG null mutations and allergic nickel dermatitis (8 3% vs. 1 3%; OR 6 75, 95% CI 1 17-38 91). | Nickel | filaggrin | Homo sapiens |
| 8 | A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8 3% vs. 2 4%; odds ratio (OR) 3 71, 95% confidence interval (CI) 0 73-18 96] as well as between FLG null mutations and allergic nickel dermatitis (8 3% vs. 1 3%; OR 6 75, 95% CI 1 17-38 91). | Nickel | filaggrin | Homo sapiens |
| 9 | CONCLUSIONS: This study suggests that FLG null mutations may be a risk factor for the development of nickel sensitization. | Nickel | filaggrin | Homo sapiens |