Pub. Date : 2010 Mar 22
PMID : 20339548
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of TGF-beta1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells. | Aspirin | transforming growth factor beta 1 | Homo sapiens |
| 2 | ASA (2 mM) induced TGF-beta1 secretion; however it was unable to induce Smad activation. | Aspirin | transforming growth factor beta 1 | Homo sapiens |
| 3 | ASA increased p38(MAPK) phosphorylation in a TGF-beta1-independent manner. | Aspirin | transforming growth factor beta 1 | Homo sapiens |
| 4 | Pre-surgical serum levels of TGF-beta1 in patients who took at antiplatelet doses ASA were assessed by ELISA and remained unchanged. | Aspirin | transforming growth factor beta 1 | Homo sapiens |
| 5 | CONCLUSIONS/SIGNIFICANCE: In vitro antiproliferative effects of aspirin (at antiinflammatory concentration) on human VSMC obtained from bypass patients are mediated by TGF-beta1 and p38(MAPK). | Aspirin | transforming growth factor beta 1 | Homo sapiens |
| 6 | Pre-surgical serum levels of TGF- beta1 from bypass patients who took aspirin at antiplatelet doses did not change. | Aspirin | transforming growth factor beta 1 | Homo sapiens |