Title : Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways.

Pub. Date : 2010 Aug

PMID : 20331638






2 Functional Relationships(s)
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1 We show that treatment of HEK293 cells with PMT inhibits staurosporine-mediated apoptosis through PI3K-dependent phosphorylation of Akt and constitutive expression of Pim-1 kinase. Staurosporine AKT serine/threonine kinase 1 Homo sapiens
2 Only the combined inhibition of Akt and Pim reverses the PMT-induced protection from staurosporine-induced apoptosis. Staurosporine AKT serine/threonine kinase 1 Homo sapiens