Pub. Date : 2010 May 27
PMID : 20307623
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | BaP is known to bind with high specificity to the aryl hydrocarbon receptor (AhR), modifying the expression of CYP1A1, involved both in cancer and inflammation. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | AhR and CYP1A1 expression was evaluated by Western blotting, which revealed their presence even in control untreated skin; both enzyme and receptor increased more than twofold after exposure to BaP. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | The results of this experiment indicate that BaP, an AhR agonist, can significantly increase receptor and CYP1A1 expression and induce oxidative stress in human skin, confirming the involvement of this pathway in the pathogenesis of tissue damage due to polycyclic aromatic hydrocarbons. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |