Title : The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.

Pub. Date : 2010 May

PMID : 20304964






1 Functional Relationships(s)
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1 Here we show that diphenyleneiodonium chloride, an inhibitor of Nox oxidases, and small-interfering RNA-mediated down-regulation of p22(phox) inhibit Akt-dependent phosphorylation of tuberin and stabilizes tuberin protein levels in VHL-deficient renal carcinoma cells. diphenyleneiodonium AKT serine/threonine kinase 1 Homo sapiens