Pub. Date : 1991 Feb
PMID : 2024291
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FLAP: a novel drug target for inhibiting the synthesis of leukotrienes. | Leukotrienes | arachidonate 5-lipoxygenase activating protein | Homo sapiens |
| 2 | FLAP (5-lipoxygenase-activating protein) is a novel 18 kDa membrane protein that together with 5-lipoxygenase is required for cellular leukotriene biosynthesis. | Leukotrienes | arachidonate 5-lipoxygenase activating protein | Homo sapiens |
| 3 | Tony Ford-Hutchinson describes a novel class of leukotriene biosynthesis inhibitor, exemplified by MK0886, that can bind to FLAP with high affinity, prevent the activation of 5-lipoxygenase by preventing the translocation of the enzyme from the cytosol to the membrane and inhibit leukotriene production. | Leukotrienes | arachidonate 5-lipoxygenase activating protein | Homo sapiens |
| 4 | Tony Ford-Hutchinson describes a novel class of leukotriene biosynthesis inhibitor, exemplified by MK0886, that can bind to FLAP with high affinity, prevent the activation of 5-lipoxygenase by preventing the translocation of the enzyme from the cytosol to the membrane and inhibit leukotriene production. | Leukotrienes | arachidonate 5-lipoxygenase activating protein | Homo sapiens |