Pub. Date : 2010 May 15
PMID : 20235151
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenic activated c-RET kinase with promotion of disulfide bond-mediated dimerization of c-RET protein. | Disulfides | ret proto-oncogene | Homo sapiens |
| 2 | Arsenic further activated RET-MEN2A kinase, which was already 3- to 10-fold augmented by genetic mutation compared with c-RET kinase activity, with promotion of disulfide bond-mediated dimerization of RET-MEN2A protein (superactivation). | Disulfides | ret proto-oncogene | Homo sapiens |
| 3 | Arsenic also increased extracellular domain-deleted RET-PTC1 kinase activity with promotion of disulfide bond-mediated dimerization of RET-PTC1 protein. | Disulfides | ret proto-oncogene | Homo sapiens |