Title : Induction of pulmonary carcinogenesis in Wistar rats by a single dose of 9, 10 dimethylbenz(a)anthracene (DMBA) and the chemopreventive role of diclofenac.

Pub. Date : 2010 Jun

PMID : 20233591






1 Functional Relationships(s)
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1 OBJECTIVES: To evaluate the chemopreventive efficacy of Diclofenac, a preferential cyclooxygenase-2 (COX-2) inhibiting non steroidal anti-inflammatory drug (NSAID) in the 9, 10 Dimethylbenz(a)anthracene (DMBA) induced experimental lung carcinogenesis. anthracene prostaglandin-endoperoxide synthase 2 Rattus norvegicus