Title : Galpha12 is critical for TCR-induced IL-2 production and differentiation of T helper 2 and T helper 17 cells.

Pub. Date : 2010 Apr 9

PMID : 20233578






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 While PMA plus ionomycin induced equal levels of IL-2 production in WT and Galpha12-deficient lymphocytes, TCR-triggered IL-2 production was significantly attenuated in Galpha12 KO lymphocytes. Ionomycin interleukin 2 Homo sapiens
2 While IL-2 expression was still diminished by the re-stimulation with anti-CD3, PMA plus ionomycin restored IL-2 production in Galpha12-deficient Th1 and Th2 cells. Ionomycin interleukin 2 Homo sapiens
3 While IL-2 expression was still diminished by the re-stimulation with anti-CD3, PMA plus ionomycin restored IL-2 production in Galpha12-deficient Th1 and Th2 cells. Ionomycin interleukin 2 Homo sapiens