Title : Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances.

Pub. Date : 2010 Sep

PMID : 20230877






6 Functional Relationships(s)
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1 Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances. rosmarinic acid prolyl endopeptidase Homo sapiens
2 In this study, we observed that rosmarinic acid (RA) inhibits POP activity with an IC(50) of 63.7 microM. rosmarinic acid prolyl endopeptidase Homo sapiens
3 In this study, we observed that rosmarinic acid (RA) inhibits POP activity with an IC(50) of 63.7 microM. rosmarinic acid prolyl endopeptidase Homo sapiens
4 The results demonstrated that RA is non-competitive POP inhibitor and that acute and subchronic RA treatments showed an inverted U-shaped dose-response curve in the platform crossings. rosmarinic acid prolyl endopeptidase Homo sapiens
5 The results demonstrated that RA is non-competitive POP inhibitor and that acute and subchronic RA treatments showed an inverted U-shaped dose-response curve in the platform crossings. rosmarinic acid prolyl endopeptidase Homo sapiens
6 These results suggest that RA has a cognitive-enhancing effect which may be mediated by inhibition of POP. rosmarinic acid prolyl endopeptidase Homo sapiens