Title : Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases.

Pub. Date : 2010 Jul

PMID : 20228251






1 Functional Relationships(s)
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1 Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with D,L-buthionine-S,R-sulfoximine (BSO) causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y cells and stimulates them to release TNF-alpha, IL-6, and nitrite ions. Glutathione tumor necrosis factor Homo sapiens