Pub. Date : 2010 Jun
PMID : 20228127
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Radioiodine remains the only tumoricidal therapy for disseminated thyroid carcinomas; however, dedifferentiated tumors lose the expression of human sodium-iodide symporter (hNIS) gene, and cannot respond to this treatment. | Iodine-131 | solute carrier family 5 member 5 | Homo sapiens |
| 2 | Previous studies suggested that a trans-active protein factor (NIS-repressor) represses endogenous hNIS transcription, likely contributing to the loss of radioiodine uptake, and defined the NIS-repressor binding site (NRBS) in the proximal hNIS promoter. | Iodine-131 | solute carrier family 5 member 5 | Homo sapiens |
| 3 | Previous studies suggested that a trans-active protein factor (NIS-repressor) represses endogenous hNIS transcription, likely contributing to the loss of radioiodine uptake, and defined the NIS-repressor binding site (NRBS) in the proximal hNIS promoter. | Iodine-131 | solute carrier family 5 member 5 | Homo sapiens |
| 4 | Previous studies suggested that a trans-active protein factor (NIS-repressor) represses endogenous hNIS transcription, likely contributing to the loss of radioiodine uptake, and defined the NIS-repressor binding site (NRBS) in the proximal hNIS promoter. | Iodine-131 | solute carrier family 5 member 5 | Homo sapiens |
| 5 | Previous studies suggested that a trans-active protein factor (NIS-repressor) represses endogenous hNIS transcription, likely contributing to the loss of radioiodine uptake, and defined the NIS-repressor binding site (NRBS) in the proximal hNIS promoter. | Iodine-131 | solute carrier family 5 member 5 | Homo sapiens |
| 6 | NIS-repressor, including its PARP-1 component, presents a potential therapeutic target to restore radioiodine uptake in dedifferentiated thyroid carcinomas. | Iodine-131 | solute carrier family 5 member 5 | Homo sapiens |