Title : Calculation of competitive inhibition of substrate binding to cytochrome P-450 illustrated by the interaction of d,l-propranolol with d,l-hexobarbital.

Pub. Date : 1980 Mar 1

PMID : 20227951






2 Functional Relationships(s)
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1 Calculation of competitive inhibition of substrate binding to cytochrome P-450 illustrated by the interaction of d,l-propranolol with d,l-hexobarbital. Propranolol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 The method is illustrated by the competitive interaction of d,l-hexobarbital and d,l-propranolol with cytochrome P-450 which show only a partial overlap for type I binding sites using rat hepatic microsomes. Propranolol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus