Title : Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia.

Pub. Date : 2010 Apr 15

PMID : 20227880






1 Functional Relationships(s)
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1 Variation of the 6-substitutent in the indene core in combination with a pendant electron rich heterocycle led to the identification of several potent H(1)-antihistamines with desirable selectivity over CYP enzymes, the M(1) muscarinic receptor and the hERG channel. indene peptidylprolyl isomerase G Homo sapiens