Pub. Date : 2010 May
PMID : 20226460
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. | Palmitic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | RESULTS: PA increased EPCs apoptosis in a dose- and time-dependent manner, upregulated phosphorylated-p38 and -JNK, caspase-3 expression of EPCs while ERK expression was not affected. | Palmitic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | PA-induced EPCs apoptosis could be partly ameliorated by p38 inhibitor SB203580 and JNK inhibitor SP600125, but not by ERK1/2 inhibitor PD98059. | Palmitic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | CONCLUSION: These findings suggested that PA promoted EPCs apoptosis via p38 and JNK MAPKs pathways. | Palmitic Acid | mitogen-activated protein kinase 8 | Homo sapiens |