Title : Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways.

Pub. Date : 2010 May

PMID : 20226460






4 Functional Relationships(s)
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1 Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Palmitic Acid mitogen-activated protein kinase 8 Homo sapiens
2 RESULTS: PA increased EPCs apoptosis in a dose- and time-dependent manner, upregulated phosphorylated-p38 and -JNK, caspase-3 expression of EPCs while ERK expression was not affected. Palmitic Acid mitogen-activated protein kinase 8 Homo sapiens
3 PA-induced EPCs apoptosis could be partly ameliorated by p38 inhibitor SB203580 and JNK inhibitor SP600125, but not by ERK1/2 inhibitor PD98059. Palmitic Acid mitogen-activated protein kinase 8 Homo sapiens
4 CONCLUSION: These findings suggested that PA promoted EPCs apoptosis via p38 and JNK MAPKs pathways. Palmitic Acid mitogen-activated protein kinase 8 Homo sapiens