Title : Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

Pub. Date : 2010 Oct 1

PMID : 20224070






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline. Theophylline histone deacetylase 2 Homo sapiens
2 Corticosteroid insensitivity and reduced histone deacetylase-2 activity after oxidative stress were reversed by a non-selective PI3K inhibitor (LY294002) and low concentrations of theophylline. Theophylline histone deacetylase 2 Homo sapiens