Pub. Date : 2010 May
PMID : 20222094
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A role for the pregnane X receptor in flucloxacillin-induced liver injury. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify genes changing in expression in response to flucloxacillin. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 5 | The ability of flucloxacillin to act as a PXR agonist was investigated with reporter gene experiments. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 6 | Using a luciferase-everted repeat separated by 6 base pairs element construct, we confirmed that flucloxacillin was a PXR agonist. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 7 | We found a difference in the distribution of a PXR polymorphism (rs3814055; C-25385T) between flucloxacillin DILI cases and controls with the CC genotype associated with an increased risk of disease (odds ratio = 3.37, 95% confidence interval = 1.55-7.30, P = 0.0023). | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 8 | CONCLUSION: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 9 | CONCLUSION: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI. | Floxacillin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |