Title : Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers.

Pub. Date : 2010 Jun

PMID : 20220747






2 Functional Relationships(s)
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1 Organ transplant recipients who have dyslipidemia related to immunosuppression may benefit from cholesterol-lowering therapy with ezetimibe, a substrate of ABCB1, ABCC2, and OATP1B1. Ezetimibe ATP binding cassette subfamily B member 1 Homo sapiens
2 However, competition between sirolimus and ezetimibe for ABCB1 and OATP1B1 is not of major clinical relevance, as confirmed in our randomized, controlled, single-dose study in healthy subjects. Ezetimibe ATP binding cassette subfamily B member 1 Homo sapiens