Title : Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif.

Pub. Date : 2010 May

PMID : 20219919






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A3G is packaged into human immunodeficiency virus type 1 virions and deaminates deoxycytidine to deoxyuridine on nascent minus-strand retroviral cDNA, leading to hyper-deoxyguanine-to-deoxyadenine mutations on positive-strand cDNA and inhibition of viral replication. Deoxycytidine apolipoprotein B mRNA editing enzyme catalytic subunit 3G Homo sapiens