Title : Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}.

Pub. Date : 2010 Jun

PMID : 20215102






1 Functional Relationships(s)
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1 Activation of ERK1/2 was inhibited by the protein kinase C (PKC) inhibitor GF 109203X as well as by the PKCdelta inhibitor rottlerin, and downregulation of PKCdelta was inhibited by small interfering RNA (siRNA), highlighting the importance of PKCdelta in the gonadotropin signalling cascade. rottlerin mitogen-activated protein kinase 3 Homo sapiens