Title : Activation of p44/42 MAPK plays a role in the TBT-induced loss of human natural killer (NK) cell function.

Pub. Date : 2010 Oct

PMID : 20213532






4 Functional Relationships(s)
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1 If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures. Tetradecanoylphorbol Acetate interferon induced protein 44 Homo sapiens
2 If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures. Tetradecanoylphorbol Acetate interferon induced protein 44 Homo sapiens
3 If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures. Tetradecanoylphorbol Acetate interferon induced protein 44 Homo sapiens
4 Western blot analysis showed that a 1-h exposure to 5 nM PMA caused a sixfold increase in phospho-p44/42 levels. Tetradecanoylphorbol Acetate interferon induced protein 44 Homo sapiens