Title : Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.

Pub. Date : 2011 Apr

PMID : 20212519






1 Functional Relationships(s)
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1 We selected 13 relevant polymorphisms in genes encoding paclitaxel metabolizing enzymes (CYP2C8, CYP3A4 and CYP3A5) and transporters (organic anion transporting polypeptide (OATP) 1B1, OATP1B3 and P-glycoprotein) and genotyped them in 118 Spanish cancer patients treated with paclitaxel. Paclitaxel cytochrome P450 family 3 subfamily A member 4 Homo sapiens